Compounded Semaglutide vs Compounded Tirzepatide
The two compounded GLP-1 options compared. Both available via telehealth without insurance — but they use different molecules with different outcomes.
14.9%
Avg weight loss Compounded Semaglutide
19.9%
Avg weight loss Compounded Tirzepatide
$90/mo
Monthly retail without insurance
$99
Lowest price via telehealth
What are they?
Both are compounded by licensed pharmacies and require a prescription. Compounded semaglutide uses a single GLP-1 mechanism; compounded tirzepatide adds GIP receptor activation for stronger outcomes.
Compounded Semaglutide
Type 2 DiabetesSemaglutide compounded by licensed pharmacies under prescriber supervision. Uses the same active molecule as Ozempic and Wegovy at equivalent doses — not individually FDA-approved, but widely available via telehealth without insurance.
Maker
Licensed Pharmacies
Approved
–
Format
Weekly injection
Max dose
2.4 mg
Compounded Tirzepatide
Weight ManagementTirzepatide compounded by licensed pharmacies under prescriber supervision. Uses the same dual GIP/GLP-1 molecule as Mounjaro and Zepbound — not individually FDA-approved, but available via telehealth at a fraction of the branded cost.
Maker
Licensed Pharmacies
Approved
–
Format
Weekly injection
Max dose
15 mg
Quick comparison
How they stack up on the metrics that matter most.
| Feature | Compounded Semaglutide | Compounded Tirzepatide |
|---|---|---|
| Active ingredient | Semaglutide | Tirzepatide |
| FDA approved for | Compounded / Off-Label | Compounded / Off-Label |
| Max dose | 2.4 mg | 15 mg |
| Avg weight loss | ~15% | ~20% |
| Administration | Weekly injection | Weekly injection |
| Insurance | Not covered | Not covered |
| Retail price/mo | $99/mo | From $149/mo |
| Telehealth price | From $99/mo | From $149/mo |
Compounded Semaglutide
Semaglutide
Compounded Tirzepatide
Tirzepatide
Compounded Semaglutide
Compounded / Off-Label
Compounded Tirzepatide
Compounded / Off-Label
Compounded Semaglutide
2.4 mg
Compounded Tirzepatide
15 mg
Compounded Semaglutide
~15%
Compounded Tirzepatide
~20%
Compounded Semaglutide
Weekly injection
Compounded Tirzepatide
Weekly injection
Compounded Semaglutide
Not covered
Compounded Tirzepatide
Not covered
Compounded Semaglutide
$99/mo
Compounded Tirzepatide
From $149/mo
Compounded Semaglutide
From $99/mo
Compounded Tirzepatide
From $149/mo
18.2 lbs
2 months
How you ramp up
Both medications use a gradual dose escalation to minimize side effects.
Compounded Semaglutide
- 1
0.25 mg
Weeks 1–4
- 2
0.5 mg
Weeks 5–8
- 3
1.0 mg
Weeks 9–12
- 4
1.7 mg
Weeks 13–16
- 5
2.4 mg
Weeks 17+
(Maintenance)
Compounded Tirzepatide
- 1
2.5 mg
Weeks 1–4
- 2
5 mg
Weeks 5–8
- 3
7.5 mg
Weeks 9–12
- 4
10 mg
Weeks 13–16
- 5
12.5 mg
Weeks 17–20
- 6
15 mg
Weeks 21+
(Maintenance)
What you’ll pay
Real pricing — no misleading teaser rates or hidden fees.
Compounded
Semaglutide
- Retail (no insurance)
- $99/mo
- With insurance
- Not covered
- Telehealth (compounded)
- From $99/mo
- Manufacturer savings
- N/A
Special offer
Save up to 30% EVERY month!
Compounded
Tirzepatide
- Retail (no insurance)
- From $149/mo
- With insurance
- Not covered
- Telehealth (compounded)
- From $149/mo
- Manufacturer savings
- N/A
Special offer
Save up to 30% EVERY month!
43.7 lbs
6 months
Weight loss compared
Clinical trial data showing average body weight reduction over 68 weeks.
Compounded Semaglutide (2.4 mg)
Compounded Tirzepatide (15 mg)
Placebo
What to expect
How they stack up on the metrics that matter most.
| Side Effect | Compounded Semaglutide | Compounded Tirzepatide |
|---|---|---|
| Nausea | 28% | 26% |
| Diarrhoea | 18% | 19% |
| Vomiting | 13% | 16% |
| Constipation | 12% | 13% |
| Headache | 8% | 7% |
| Fatigue | 4% | 5% |
Compounded Semaglutide
28%
Compounded Tirzepatide
26%
Compounded Semaglutide
18%
Compounded Tirzepatide
19%
Compounded Semaglutide
13%
Compounded Tirzepatide
16%
Compounded Semaglutide
12%
Compounded Tirzepatide
13%
Compounded Semaglutide
8%
Compounded Tirzepatide
7%
Compounded Semaglutide
4%
Compounded Tirzepatide
5%
Side effects are generally most pronounced during the first 4–8 weeks and tend to subside. Always consult your healthcare provider.
What people say
Verified experiences from real patients across leading telehealth platforms.
Compounded Semaglutide
4.2
5,203 reviews
Compounded Tirzepatide
4.4
2,847 reviews
“Tried compounded semaglutide first — 20 lbs in 4 months. Switched to compounded tirzepatide. Additional 38 lbs in the next 5 months. The cost difference ($129 vs $199) is absolutely worth it.”
Verified patient · 5 months on medication
“Happy with compounded semaglutide at $129/mo. Down 35 lbs in 5 months. No need to spend more on tirzepatide when I’m seeing great results already.”
Verified patient · 4 months on medication
“Both are affordable vs branded. I chose tirzepatide for the clinical data. Down 52 lbs in 7 months at $199/mo. Best cost-per-pound-lost in the market right now.”
Verified patient · 7 months total
The bottom line
Same molecule, different use cases. Here’s how to think about it.
Choose based on your goal
- Choose Compounded Semaglutide if you’re starting out and want the most affordable GLP-1 option — results are strong, risks are well understood, and costs start from $99/month.
- Choose Compounded Tirzepatide if you’re willing to spend slightly more for the dual GIP/GLP-1 mechanism — clinical data consistently shows 5–7 percentage points more weight loss vs semaglutide.
- Either way use a licensed compounding pharmacy and a prescriber who monitors your progress with regular check-ins and dose adjustments.
What you
need to know
Clinical data suggests tirzepatide, which targets both GIP and GLP-1 receptors, typically produces 5–7 percentage points more weight loss than semaglutide alone. Our comparison shows average body weight reduction of roughly 20% on compounded tirzepatide versus 15% on compounded semaglutide over 68 weeks. That said, “more effective” depends on your goals, tolerance at higher doses, and budget — a licensed provider can help weigh the trade-offs.
Both have broadly similar safety profiles when prescribed and monitored by a licensed provider. Reported side effects — nausea, digestive discomfort, headache, fatigue — are comparable across both, and tend to ease after the first 4–8 weeks as your body adjusts. Compounded versions carry the same clinical risks as their branded counterparts when dispensed by a licensed compounding pharmacy under prescriber supervision.
Compounded semaglutide typically starts around $99/month via telehealth. Compounded tirzepatide starts around $149/month. Higher dose tiers push both upward — patients at the top of the ramp report paying closer to $129/month for semaglutide and $199/month for tirzepatide. Neither is covered by insurance, since compounded preparations aren’t individually FDA-approved.
Start with compounded semaglutide if you want the most affordable entry point and a well-established side-effect profile. Consider compounded tirzepatide if you’re willing to spend slightly more for the dual GIP/GLP-1 mechanism and the higher average weight loss it tends to produce. Either way, a licensed provider will match you to the right starting dose based on your health history and goals.
Yes. Both compounded semaglutide and compounded tirzepatide require a prescription from a licensed healthcare provider. Compounded medications are prepared by licensed compounding pharmacies for individual patients, under medical supervision — so a consultation is required before you can start.
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